World’s First Non-Invasive Robotic-Assisted Bronchoscope to Benefit Patients With Lung Metastasis

Professor Ng says his research team plans to launch robotic-assisted bronchoscopic microwave ablation trials for primary lung cancer patients at the end of 2023. Courtesy of the CUHK news release center
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When cancer cells metastasize from malignant tumors in different parts of the human body, they often transfer to the lungs. The main treatment modality for lung metastases is surgical resection. Removing these tumors using traditional surgery not only increases trauma, but can inadvertently remove adjacent healthy lung tissue and diminish a patient’s lung function.

The Chinese University of Hong Kong’s (CUHK) Faculty of Medicine has conducted the world’s first procedure using the novel robotic-assisted bronchoscopic microwave ablation to successfully remove lung metastases.

This advanced technology can accurately and noninvasively remove tumors around the lungs, including peripheral areas, while maintaining the patient’s lung function by protecting healthy surrounding tissue. There are no surgical wounds required, and most patients experience no pain or blood loss.

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For those with advanced-stage metastatic cancer of the lung, this technology could be a game-changer.

The noninvasive procedure is performed by trained thoracic surgeons who use an advanced navigation platform to control the bronchoscope before accurately putting a catheter probe for ablation into the position of the lung transfer tissue. The process releases microwave energy to destroy lesion tissues.

Dr. Rainbow Lau Wing-hung, clinical assistant professor of CUHK’s division of cardiothoracic surgery, explained how the technology uses real-time imaging and electromagnetic positioning to allow navigation of the complex human airways. The bronchoscope is controlled using a remote console linked with robotic arms, allowing the ability to accurately drive the device to the exact location desired within the lung.

The mechanism maintains stability within the bronchoscope. Using a microwave ablation catheter will improve the accuracy and efficiency of the ablation procedure, he said.

Calvin Ng Sze-hang, a professor from the division of cardiothoracic surgery at CUHK, remarked:
“We are very excited to have performed the world’s first robotic-assisted bronchoscopy microwave ablation of lung metastases. By combining the benefits of precise airway navigation with robotic bronchoscopy and our world-leading experience in transbronchial microwave ablation of lung tumours, we can now give our patients with lung metastases an additional treatment option which is noninvasive.
“Often, advanced cancer patients have multiple lung metastases distributed throughout both lungs. Under these circumstances, treatment by conventional surgical resection involves bilateral surgical incisions and removal of multiple wedges of lung tissue that can significantly affect the patient’s lung function, and may even lead to delay in administration of chemotherapy as the patient recovers from surgery. Our novel approach using robotic bronchoscopic microwave ablation allows multiple bilateral lung metastases to be treated without incisions or lung resection, meaning almost no impact on patient’s lung function or quality of life.” Since October 2022, three patients with six lung metastases have been successfully treated. The technology is still in the clinical trial phase, with the intent to enroll 145 cases globally.
The diagram shows a microwave ablation mock procedure with egg yolk. The endoluminal releases microwave and heat, effectively destroying cancer cells in an environment above 60°C. (Courtesy of CUHK news release center)
The diagram shows a microwave ablation mock procedure with egg yolk. The endoluminal releases microwave and heat, effectively destroying cancer cells in an environment above 60°C. Courtesy of CUHK news release center