Study Reveals Rising Inflammatory Bowel Disease Rates Among American Youth

A comprehensive CDC-funded study highlights an increasing prevalence of Crohn’s disease and ulcerative colitis in children.
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A new study has found a rise in inflammatory bowel disease (IBD) among American youth, with nearly 100,430 children now diagnosed—marking a 22 percent increase in Crohn’s disease and a 29 percent spike in ulcerative colitis since 2009.

Researchers warn that the United States now has some of the world’s highest pediatric IBD rates, with youth in the Northeast most significantly affected.

Prevalence Varies by Race and Geography

​The study, funded by the Centers for Disease Control and Prevention (CDC) and published in Gastroenterology, represents what the authors call the most comprehensive assessment of pediatric IBD prevalence in the United States to date.​

IBD refers to chronic conditions that cause inflammation in the digestive tract. Crohn’s disease primarily affects the small and large intestines, although patches of inflammation can occur anywhere in the gastrointestinal tract, while ulcerative colitis mainly affects the colon and rectum.

The findings estimate that more than 100,000 American youth younger than the age of 20 are currently living with IBD.

Researchers analyzed data from commercial insurance claims and Medicaid datasets across five of the most populous states, providing a nationally representative picture of physician-diagnosed pediatric IBD.

The study identified a continuous rise in pediatric IBD prevalence in the United States, which is now among the highest in the world.

Their findings indicate an approximate 22 percent increase in cases of Crohn’s disease and a 29 percent increase in cases of ulcerative colitis among the pediatric population between 2009 and 2020.

Crohn’s disease (71 per 100,000) is more prevalent than ulcerative colitis (44 per 100,000) in the pediatric population. Prevalence varies significantly by race, with white youth experiencing the highest rates, followed by Asian. Crohn’s disease was more prevalent in males, while ulcerative colitis was more prevalent in females. The Northeast had higher rates than the rest of the country.

Importance of Data for Understanding IBD in Youth

The study provides crucial data to inform health care policy, resource allocation, and future research priorities in pediatric IBD, according to Dr. Michael D. Kappelman, a professor of pediatrics and epidemiology at the University of North Carolina at Chapel Hill and co-author of the study.
“This comprehensive evaluation of pediatric IBD prevalence in the U.S. is an important step in understanding the full spectrum of the disease in our youth,” Andrés Hurtado-Lorenzo, who has a doctorate in molecular medicine and gene therapy and is the senior vice president of Translational Research and IBD Ventures at the Crohn’s & Colitis Foundation, said in a statement.

While the study provides valuable insights, further research is necessary to understand the reasons behind the observed demographic and geographic variations in pediatric IBD prevalence and the reasons for the overall increase.

The pooled data analyzed represent almost the entire U.S. population with commercial and Medicaid health insurance. However, the researchers acknowledged that the study did not capture data on uninsured Americans, a demographic typically overrepresented by people of color and noncitizens.

“As the uninsured rate among children (5.1%) is half that of nonelderly adults (11.3%), the impact of this omission on our overall prevalence estimate is likely to be small,” the authors noted.

Previous research published in the journal Inflammatory Bowel Diseases has indicated potential environmental triggers linked to IBD, including:
  • Western-style diet high in ultra-processed foods, sugar, food coloring, and chemical additives
  • Exposure to antibiotics from a young age
  • Environmental pollutants such as microplastics
  • Early exposure to severe stress
George Citroner
George Citroner
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George Citroner reports on health and medicine, covering topics that include cancer, infectious diseases, and neurodegenerative conditions. He was awarded the Media Orthopaedic Reporting Excellence (MORE) award in 2020 for a story on osteoporosis risk in men.
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